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KMID : 0377220000250020052
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Medical Journal of Chosun Univercity
2000 Volume.25 No. 2 p.52 ~ p.60
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Antimicrobial Resistance of Staphyococcus aureus Isolated in Gwangju
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Shin Sung-Heui
Chang Jeong-Soo
Lim Yong
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Abstract
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Objectives : The emergence of Staphylococcus aureus showing multi-drug resistance emphasizes the importance of the prudent use of antibiotics. To survey and obtain the basic information for reappraisal of practical usefulness, we investigated the profiles of antimicrobial resistance of S. aureus isolated recently in Gwangju area.
Materials and Methods : S. aureus was isolated from community-hospitals in Gwangju and finally identified by coagulase test. The standard disc diffusion method was used for antimicrobial susceptibility test.
Results : The resistance ratio of S. aureus against amoxicillin/clavulanic acid, ciprofloxacin, clindamycin, erythromycin, gentamicin, oxacillin, phenoxymethyl penicillin, trimethoprim/sulphamethoxazole, vancomycin, cefotaxime, and imipenem/cilastatin was 61.0, 65.3, 50.0, 76.5, 76.6, 66.9, 96.7, 15.6, 0, 87.5, and 95.5%, respectively. Resistant strains to each antibiotic were more resistant to the other antibiotics than susceptible strains. The ratio of oxacillin-resistant S. aureus (ORSA) in this area has not increased for recent five years. However, the resistance of ORSA against cefotaxime and ciprofloxacin has increased significantly. ORSA was still susceptible to trimethoprim/sulphamethoxazole (78.3%) and vancomycin (100%)
Conclusion : These results offer the latest information about the antimicrobial resistance of S. aureus in Gwangju area and will be used hr reappraisal and selection of antibiotics effective against S. aureus.
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KEYWORD
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Staphylococcus aureus, antimicrobial resistantce, axacillin-resistant S.aureus(ORSA)
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